The International Conference on E-Science and Open Science (ICESOS - 25) will be held in Thimphu, Bhutan on 4th - 5th December 2025 in both physical and virtual modes. It aims to bring together researchers, scientists, academicians, policymakers, and industry experts to share their experiences and knowledge in their respective fields. This conference will provide a platform for attendees to exchange ideas, discuss research findings, and network with one another. (ICESOS - 25) offers a valuable opportunity for participants to learn about the latest advancements and developments in their field.